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Angiogenesis and liver fibrogenesis

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dc.contributor.authorValfrè di Bonzo, Lorenzoes
dc.contributor.authorNovo, Ericaes
dc.contributor.authorCannito, Stefania
dc.contributor.authorBusletta, Chiara
dc.contributor.authorPaternostro, Claudia
dc.contributor.authorPovero, Davide
dc.contributor.authorParola, Maurizio
dc.date.accessioned2014-01-09T10:34:38Z
dc.date.available2014-01-09T10:34:38Z
dc.date.issued2009
dc.description.abstractAngiogenesis is a dynamic, hypoxiastimulated and growth factor-dependent process, eventually leading to the formation of new vessels from pre-existing blood vessels. In the last decade experimental and clinical studies have described the occurrence of hepatic angiogenesis in a number of different pathophysiological conditions, including those involving inflammatory, fibrotic and ischemic features. In particular, the literature evidence indicates that hepatic angiogenesis is strictly associated with, and may even favour fibrogenic progression of chronic inflammatory liver diseases of different aetiology. In this review, current “in vivo” and “in vitro” evidence supporting the potential pathogenetic role of angiogenesis in chronic liver diseases will be reviewed in an attempt to outline cellular and molecular mechanisms involved, with a specific emphasis on the crucial role of hypoxic conditions and hepatic stellate cells (HSCs), particularly when activated to the myofibroblast-like pro-fibrogenic phenotype.es
dc.formatapplication/pdfes
dc.format.extent19es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37533
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAngiogenesises
dc.subjectHepatic stellate cellses
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleAngiogenesis and liver fibrogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº10 (2009)