Publication: Disposition kinetics and bioavailability of doxycycline after parenteral administrations in ewes
Authors
Martínez, José ; Escudero Pastor, Elisa ; Badillo Puerta, Elena ; Yuste Pérez, María Teresa ; Galecio Naranjo, Juan Sebastian ; Marín Carrillo, Pedro
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.rvsc.2024.105412
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info:eu-repo/semantics/article
Description
© 2024 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Published Manuscript, version of a Published Work that appeared in final form in Research in Veterinary Science. To access the final edited and published work see https://doi.org/10.1016/j.rvsc.2024.105412
Abstract
Doxycycline is a tetracycline, which have been marketed in different species for treating infections caused by
susceptible bacteria. There is limited information on the disposition kinetics of this drug in ewes and this
antimicrobial may be useful against several sheep pathogens that are common causes of morbidity and economic
loss. Therefore, the aim of this work was to establish the pharmacokinetics of doxycycline after intravenous (IV)
and extravascular (subcutaneous (SC) and intramuscular (IM)) administrations in this species. A cross-over
model was designed (n = 6). Doxycycline was dosed at 5 mg/kg for IV administration and 20 mg/kg for
extravascular administrations. Non-compartmental pharmacokinetic methods were used to calculate plasma
concentration-time data. The value of apparent volume of distribution (Vz) suggests a moderate distribution of
this antibiotic in sheep, with a value of 0.84 L/kg. The maximum concentrations achieved after extravascular
administrations (Cmax) were similar, with no significant differences between the two routes of administration (IM
and SC). However, doxycycline absorption was slower after SC administration than after IM administration,
taking twice as long to reach maximum plasma concentration (tmax). Bioavailabilities after extravascular routes
of administration were low and after IM administration doxycycline caused lameness in all animals. Therefore,
the SC administration showed a better profile with respect to pharmacokinetic properties and safety. Future
studies on the susceptibility of isolated sheep pathogens to doxycycline are needed to establish appropriate
dosing regimens.
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Citation
Research in Veterinary Science, 2024, Vol. 180 : 105412
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/