Publication: Cell adhesion molecules in stromal corneal dystrophies
Authors
Nemeth, Gabor ; Felszeghy, Szabolcs ; Kenyeres, Annamaria ; Szentmáry, Nora ; Berta, Andras ; Süveges, Ildiko ; Módis, Laszlo
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of the present study was to
investigate the expression pattern of different cell
adhesion molecules in corneal stromal dystrophies.
Fifteen corneal buttons from patients diagnosed with
three different types of stromal corneal dystrophies and
healthy corneas were investigated. Paraffin embedded
sections were stained immunohistochemically with
monoclonal antibodies against human intercellular
adhesion molecule-1 (ICAM-1), endothelial selectin (Eselectin)
and endothelial cadherin (E-cadherin) using the
avidin-biotin-peroxidase-complex technique. The
sections were compared to normal eye bank controls.
In corneas from granular dystrophy patients ICAM-1
was expressed focally in epithelial cells and in
keratocytes, and expressed diffusely in endothelial cells.
In corneas from macular dystrophy patients diffuse
epithelial staining was observed and the stromal and
endothelial expression was found to be similar to that of
granular dystrophy. In lattice dystrophy, only the
epithelial cells and endothelium were intensively
positive for ICAM-1. E-selectin was not present on any layer of the corneal specimens. E-cadherin was observed
only in the epithelium of all three types of corneal
dystrophies. Normal corneas did not express any of the
investigated adhesion molecules.
We found different expression patterns of adhesion
molecules in corneas from stromal dystrophies. Our
results suggest that adhesion molecules may be involved
in the pathogenesis of corneal stromal dystrophies.
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