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Evaluation of Changes in Metabolites of Saliva in Canine Obesity Using a Targeted Metabolomic Approach

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dc.contributor.authorMuñoz-Prieto, Alberto
dc.contributor.authorRubić, Ivana
dc.contributor.authorHorvatić, Anita
dc.contributor.authorRafaj, Renata Barić
dc.contributor.authorCerón, José Joaquín
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorMrljak, Vladimir
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2024-02-09T23:56:28Z
dc.date.available2024-02-09T23:56:28Z
dc.date.issued2021-07-26
dc.description©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published, version of a Published Work that appeared in final form in Animals. To access the final edited and published work see https://doi.org/10.3390/ani11092501es
dc.description.abstractObesity is a common problem in pet dogs, affecting half of the general population in some countries. Excess body weight causes several disorders and has a negative impact on dogs’ quality of life. The use of metabolomics allows the identification of metabolite traces from the metabolic pathways involved in pathological processes. This study aimed to evaluate salivary metabolite variations in dogs with obesity. The salivary samples of 19 dogs were analyzed using a targeted metabolomic approach, through which 234 metabolites were quantified. Of these, multivariate analysis identified 27 different metabolites altered in dogs with obesity compared with control dogs. These metabolites were mainly classified as amino acids, glycerides, sphingolipids, glycerophospholipids, and acylcarnitines. Some of the changes in these metabolites reflect the insulin resistance status related to obesity in dogs. Overall, it can be concluded that the salivary metabolome of obese dogs reflects the metabolic changes occurring in obesity and could be a source of potential biomarkers for this complex condition.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationAnimals, volumen 11, issue 9
dc.identifier.doihttps://doi.org/10.3390/ani11092501
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10201/139184
dc.languageenges
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectObesityes
dc.subjectDogses
dc.subjectSalivaes
dc.subjectTargeted metabolomicses
dc.subjectBiomarkerses
dc.titleEvaluation of Changes in Metabolites of Saliva in Canine Obesity Using a Targeted Metabolomic Approaches
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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