Publication:
The pathologic diagnosis of mantle cell lymphoma

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Li-36-1037-1051-2021.pdf(8.47 MB)
Date
2021
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Authors
Li, Shaoying ; Xu, Jie ; You, James
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-351
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info:eu-repo/semantics/article
Description
Abstract
Mantle cell lymphoma (MCL) is a mature Bcell non-Hodgkin lymphoma usually characterized by t(11;14) (q13;q32), or CCND1 translocation and Cyclin D1 over expression. A very small subset of MCL may lack the t(11;14) (q13;q32) translocation and Cyclin D1 over expression, but show alternative translocations involving CCND2 and CCND3, and over expression of SOX11. In general, MCL has been considered a very aggressive and incurable lymphoma and patients with MCL usually have a poor prognosis. However, indolent variants, including in situ mantle cell neoplasm and the recently recognized leukemic non-nodal MCL do exist. In recent years, genome-wide molecular genetic studies have revealed a characteristic MCL genetic profile. This review will focus on the pathologic diagnosis of MCL using the traditional morphological and immunophenotypic strategies combined with cytogenetic characteristics and recently identified molecular profile. Morphological subtypes, immunophenotypic variants, recently recognized indolent variants, as well as MCL risk stratification will also be discussed.
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Mantle cell lymphoma , CyclinD1 , CCND1 , SOX11
Citation
Histology and Histopathology Vol. 36, nº10 (2021)
URI
http://hdl.handle.net/10201/127897
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Histology and histopathology Vol.36,nº10 (2021)
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