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Complementary research models and methods to study axonal regeneration in the vertebrate retinofugal system

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dc.contributor.authorBollaerts, Ilse
dc.contributor.authorVeys, Lien
dc.contributor.authorGeeraerts, Emiel
dc.contributor.authorAndries, Lien
dc.contributor.authorDe Groef, Lies
dc.contributor.authorBuyens, Tom
dc.contributor.authorMoons, Lieve
dc.contributor.authorVan Hove, Inge
dc.contributor.authorSalinas Navarro, Manuel Ángel
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.date.accessioned2026-03-05T09:44:24Z
dc.date.available2026-03-05T09:44:24Z
dc.date.copyright© The Author(s) 2017
dc.date.issued2018
dc.description.abstractDue to the lack of axonal regeneration, age-related deterioration in the central nervous system (CNS) poses a significant burden on the wellbeing of a growing number of elderly. To overcome this regenerative failure and to improve the patient’s life quality, the search for novel regenerative treatment strategies requires valuable (animal) models and techniques. As an extension of the CNS, the retinofugal system, consisting of retinal ganglion cells that send their axons along the optic nerve to the visual brain areas, has importantly contributed to the current knowledge on mechanisms underlying the restricted regenerative capacities and to the development of novel strategies to enhance axonal regeneration. It provides an extensively used research tool, not only in amniote vertebrates including rodents, but also in anamniote vertebrates, such as zebrafish. Indeed, the latter show robust regeneration capacities, thereby providing insights into the factors that contribute to axonal regrowth and proper guidance, complementing studies in mammals. This review provides an integrative and critical overview of the classical and state-of-the-art models and methods that have been employed in the retinofugal system to advance our knowledge on the signaling pathways underlying the restricted versus robust axonal regeneration in rodents and zebrafish, respectively. In vitro, ex vivo and in vivo models and techniques to improve the visualization and analysis of regenerating axons are summarized. As such, the retinofugal system is presented as a valuable model to further facilitate research on axonal regeneration and to open novel therapeutic avenues for CNS pathologies.
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dc.identifier.citationBollaerts, I., Veys, L., Geeraerts, E., Andries, L., De Groef, L., Buyens, T., ... & Van Hove, I. (2018). Complementary research models and methods to study axonal regeneration in the vertebrate retinofugal system. Brain Structure and Function, 223(2), 545-567.
dc.identifier.doihttps://doi.org/10.1007/s00429-017-1571-3
dc.identifier.eissn1863-2661
dc.identifier.issn1863-2653
dc.identifier.urihttp://hdl.handle.net/10201/218381
dc.languageeng
dc.publisherSpringer
dc.relationThe authors are financially supported by national Hercules Grants (AKUL/09/038 and AKUL1309) and Grants from the Research Council of KU Leuven (KU Leuven BOF-OT/10/033), the Research Foundation Flanders (Belgium, FWO G.0054.12, G0B2315N and fellowships to IB and LDG), and Flanders Innovation and Entrepreneurship (Belgium, IWT, fellowships to EG, TB and IVH).
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00429-017-1571-3
dc.rightsAttribution 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOptic nerve injury
dc.subjectRodents
dc.subjectZebrafish
dc.subjectAxonal regeneration
dc.subjectVisual behavior
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleComplementary research models and methods to study axonal regeneration in the vertebrate retinofugal system
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication81da925b-fa46-4a1a-96fd-ce35568fa423
relation.isAuthorOfPublication.latestForDiscovery81da925b-fa46-4a1a-96fd-ce35568fa423
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