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Cerebrovascular amyloidosis: Experimental analysis in vitro and in vivo

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dc.contributor.authorWalker, L.C.es
dc.contributor.authorDurham, R.A.es
dc.date.accessioned2011-02-22T11:09:22Z
dc.date.available2011-02-22T11:09:22Z
dc.date.issued1999
dc.description.abstractWith advancing age, the likelihood of Bamyloid deposition in the cerebral vasculature increases, particularly in individuals with Alzheimer's disease. The B-amyloid typically accumulates in the basal lamina of the arteriolar tunica media, and frequently extends into the adjacent neuropil. Cerebrovascular B-amyloid increases the risk of hemorrhagic stroke, and may also play a role in the pathogenesis of AD. Genetic variations have been identified that are causative or risk factors for cerebrovascular B-amyloid, including particular mutations in the genes for 0-amyloid precursor protein, presenilins 1 and 2, and possibly cystatin C, as well as polymorphisms in apolipoprotein E. Cerebrovascular amyloidosis is now being studied in a variety of in vitro and in vivo models, including cultured vascular smooth muscle cells, transgenic mice, and aged animals such as nonhuman primates. Methods for delivering agents selectively to vascular amyloid in living subjects are now being developed, and these techniques are paving the way to the development of diagnostic tools and therapies for cerebrovascular amyloidosis.en_EN
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19207
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyen_EN
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAlzheimer's diseaseen_EN
dc.subjectTransgenic miceen_EN
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes
dc.titleCerebrovascular amyloidosis: Experimental analysis in vitro and in vivoen_EN
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 3 (1999)