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Bone union formation in the rat mandibular symphysis using hydroxyapatite with or without simvastatin: effects on healthy, diabetic, and osteoporotic rats

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dc.contributor.authorCamacho Alonso, Fabio
dc.contributor.authorMartínez Ortiz, C.
dc.contributor.authorPlazas Buendía, L.
dc.contributor.authorMercado Díaz, A.M.
dc.contributor.authorVilaplana Vivo, C.
dc.contributor.authorMerino, J.J:
dc.contributor.authorMartínez Beneyto, Yolanda
dc.contributor.authorNavarro Cámara, José Antonio
dc.contributor.authorBuendía Marín, Antonio Julián
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-01-31T18:02:28Z
dc.date.available2024-01-31T18:02:28Z
dc.date.issued2020-01-11
dc.description© Springer-Verlag GmbH Germany, part of Springer Nature 2020. This document is the Published version of a Published Work that appeared in final form in Clinical Oral Investigations. To access the final edited and published work see https://doi.org/10.1007/s00784-019-03180-9
dc.description.abstractObjective The objective is to compare new bone formation in critical defects in healthy, diabetic, and osteoporotic rats filled with hydroxyapatite (HA) alone and HA combined with simvastatin (SV). Materials and methods A total of 48 adult female Sprague-Dawley rats were randomized into three groups (n = 16 per group): Group, 1 healthy; Group 2, diabetics; and Group 3, osteoporotics. Streptozotocin was used to induce type 1 diabetes in Group 2, while bilateral ovariectomy was used to induce osteoporosis in Group 3. The central portion of the rat mandibular symphysis was used as a physiological critical bone defect. In each group, eight defects were filled with HA alone and eightwithHA combined with SV. The animals were sacrificed at 4 and 8 weeks, and the mandibles were processed for micro-computed tomography to analyze radiological union and bone mineral density (BMD); histological analysis of the bone union; and immunohistochemical analysis, which included immunoreactivity of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP-2). Results In all groups (healthy, diabetics, and osteoporotics), the defects filled with HA+ SV presented greater radiological bone union, BMD, histological bone union, and more VEGF and BMP-2 positivity, in comparison with bone defects treated with HA alone. Conclusions Combined application ofHAand SVimproves bone regeneration in mandibular critical bone defects compared with application of HA alone in healthy, diabetic, and osteoporotic rats. Clinical relevance This studymight help to patients with osteoporosis or uncontrolled diabetes type 1, but future studies should be done.es
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dc.format.extent13es
dc.identifier.citationClinical Oral Investigations 2020 24(4):1479-1491
dc.identifier.doihttps://doi.org/10.1007/s00784-019-03180-9
dc.identifier.issnElectronic: 1436-3771
dc.identifier.urihttp://hdl.handle.net/10201/138308
dc.languageenges
dc.publisherSpringer Heidelberges
dc.relationSin financiación externa a la Universidades
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHydroxyapatitees
dc.subjectSimvastatines
dc.subjectCritical bone defectes
dc.subjectMandibular symphysises
dc.subjectBone regenerationes
dc.subjectRatses
dc.subjectDiabeteses
dc.subjectOsteoporosises
dc.subject.otherCDU::5 - Ciencias puras y naturaleses
dc.titleBone union formation in the rat mandibular symphysis using hydroxyapatite with or without simvastatin: effects on healthy, diabetic, and osteoporotic ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication41991b8b-3a95-46de-ab2a-b7968ee121e6
relation.isAuthorOfPublicationc084ce85-206c-418d-8cec-7f85a0f34dc0
relation.isAuthorOfPublication.latestForDiscovery41991b8b-3a95-46de-ab2a-b7968ee121e6
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