Publication: Role of skeletal muscle in the epigenetic shaping of motor neuron fate choices
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Date
2009
Authors
Angka, Heather E. ; Kablar, Boris
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We study the role of muscle in the epigenetic
(N.B., we use this term with the broader and more
integrative meaning) shaping of developing motor
neuron fate choices employing an approach based on
mouse mutagenesis and pathology. The developmental
role of skeletal muscle is studied in the whole mouse
embryo by knocking out myogenic regulatory factors
Myf5 and MyoD, to obtain an embryo without any
skeletal musculature (Rudnicki et al., 1993). Our goal is
to find muscle-provided trigger(s) of motor neuron death
relevant to motor neuron diseases such as amyotrophic
lateral sclerosis. The reason for this kind of thinking is
the fact that a complete absence of lower and upper
motor neurons, which is the pathological definition of
amyotrophic lateral sclerosis, is only achieved in the
complete absence of the muscle (Kablar and Rudnicki,
1999). Mutual embryonic inductive interactions between
different tissue types and organs, between individual cell
types belonging to the same or different lineages, and
between various kinds of molecular players, are only
some examples of the complex machinery that operates
to connect genotype and phenotype. So far, our studies
indicate that some aspects of this interplay can indeed be
studied as proposed in this review article, suggesting the
role of skeletal muscle in the epigenetic shaping of
motor neuron fate choices. We will therefore continue
this investigation as outlined to gain more insight into
the nature of the epigenetic events that lead to the
emergent properties of a phenotype.
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