New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities

López-Muñoz, Azucena; Meseguer Peñalver, J.; Mulero Méndez, Victoriano Francisco; Roca Soler, Francisco José

Publication:
New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities

dc.contributor.author	López-Muñoz, Azucena
dc.contributor.author	Meseguer Peñalver, J.
dc.contributor.author	Mulero Méndez, Victoriano Francisco
dc.contributor.author	Roca Soler, Francisco José
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2025-01-29T16:57:32Z
dc.date.available	2025-01-29T16:57:32Z
dc.date.issued	2009-03-15
dc.description	© 2009 by The American Association of Immunologists, Inc. This document is the Published version of a Published Work that appeared in final form in The Journal of Immunology. To access the final edited and published work see https://doi.org/10.4049/jimmunol.0802528
dc.description.abstract	The IFNs and their receptors have existed in early chordates for ∼500 million years and represent the early elements in innate and adaptive immunity. Both types I and II IFNs have been discovered in fish, and type I has recently been classified into two groups based on their primary protein sequences. However, the biological activities of fish IFNs and their roles in infection are largely unknown. Using the zebrafish and manageable bacterial (Streptococcus iniae) and viral (spring viremia of carp virus) infection models, we are reporting in this study that zebrafish IFN (zfIFN) γ failed to induce antiviral and proinflammatory genes when administered in vivo, which correlates with its inability to protect the fish against bacterial and viral infections. We also found that, although both group I (i.e., zfIFN1) and group II zfIFNs (i.e., zfIFN2 and zfIFN3) displayed strong in vivo antiviral activities, only group I zfIFN was able to protect the fish against bacterial infection, which may reflect the different patterns and kinetics of immune-related genes elicited by these two groups of IFNs. Thus, group II zfIFNs induced a rapid and transient expression of antiviral genes, whereas group I zfIFN exerted a slow but more powerful induction of several antiviral and proin-flammatory genes. Collectively, our results suggest nonredundant, complementary roles of type I zfIFNs in viral infections and provide evidence for a pivotal role of the recently identified group II IFN of fish in the early stages of viral infections.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	The Journal of Immunology 2009, 182: 3440 –3449
dc.identifier.doi	https://doi.org/10.4049/jimmunol.0802528
dc.identifier.issn	Print: 0022-1767
dc.identifier.issn	Electronic: 1550-6606
dc.identifier.uri	http://hdl.handle.net/10201/149654
dc.language	eng	es
dc.publisher	American Association of Immunologists, Oxford University Press	es
dc.relation	Spanish Ministry of Education and Science (Grants BIO2005-05078 and CSD2007-00002), the Fundación Séneca-Murcia (Grant 04538/GERM/06), the Fundación Marcelino Botín, and the University of Murcia (fellowships to A.L.-M.)	es
dc.relation.publisherversion	https://journals.aai.org/jimmunol/article/182/6/3440/103690/New-Insights-into-the-Evolution-of-IFNs-Zebrafish
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	IFN	es
dc.subject	Evolution	es
dc.subject	Antiviral activity	es
dc.subject	Fish	es
dc.subject	Infection	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica	es
dc.title	New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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relation.isAuthorOfPublication.latestForDiscovery	369f9ade-8896-4d91-84c5-e3f94a526070