Publication: Morphometric studies on the development of the human thyroid gland. II. The late fetal life
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Date
1997
Authors
Bocian-Sobkowska, J. ; Wozniak, W. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Histological and morphometric studies were
performed on 27 thyroid glands obtained from normal
fetuses ranging between 23 to 40 weeks of intra-uterine
life.
In the thyroids the volume of gland, colloid, and
stroma were calculated by means of differential pointcounting
method and the height of the thyroid follicular
cells was measured. Moreover, the epithelium/colloid
ratio in the thyroid gland, a very sensitive parameter of
stimulation of the glands by TSH, was calculated.
Regarding the values of this ratio in human fetal thyroid
gland, the intra-uterine development of the gland may be
divided into three distinct stages. The first one, between
weeks 10- 18 is characterized by massive folliculogenesis
and gradual accumulation of the colloid. The second
stage, between weeks 19-29 of fetal life is characterized
by rather unchanged values of epithelium/colloid ratio
and the size of follicles. The third stage, after the 29th
week of development is characterized by a gradual
increase in the epithelium/colloid ratio and a decrease in
the size of follicles.
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