Publication:
Expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type

Simple item page
dc.contributor.authorFeng, Yuhua
dc.contributor.authorZhong, Meizuo
dc.contributor.authorLiu, Yiping
dc.contributor.authorWang, Leyuan
dc.contributor.authorTang, Youhong
dc.date.accessioned2022-04-05T10:54:09Z
dc.date.available2022-04-05T10:54:09Z
dc.date.issued2018
dc.description.abstractObjective. To investigate the expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type (ENKTL), and evaluate the clinical and prognostic significance of TIM-3 and LAG-3 in ENKTL. Methods. A total of 61 human paraffin-embedded specimens including 41 ENKTL and 20 rhinitis were involved. We performed immunohistochemistry to detect the expression of TIM-3 and LAG-3. We analyzed correlation between expression of TIM-3 and LAG-3 and clinicopathological features of ENKTL. Results. TIM-3 was positively expressed in 95 (39/41) ENKTL compared with 55% (11/20) in rhinitis, LAG-3 was positively expressed in 95 (39/41) ENKTL compared with 45% (9/20) in rhinitis. A positive correlation was found between TIM-3 and LAG-3. TIM3 and LAG-3 had no significant correlation with ENKTL patients’ age, gender, international prognostic index (IPI) score, B symptoms, LDH level, Ann Arbor stage and treatment regimens. High expression of TIM-3, high IPI score, elevated LDH level and late Ann Arbor stage were shown to be correlated with worse progression free survival (PFS). A multivariate COX regression model show that TIM-3 high expression rate was an independent prognostic factor for ENKTL patients’ PFS. Conclusions. Our findings indicate that TIM-3 might be a promising predictive indicator for the ENKTL patients.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, Vol.33, nº3, (2018)
dc.identifier.doiDOI. 10.14670/HH-11-931
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118733
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectExtranodal NK/T cell lymphomaes
dc.subjectNasal typees
dc.subjectTIM-3es
dc.subjectLAG-3es
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal typees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Feng-33-307-315-2018.pdf
Size:
8.58 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.33, nº3 (2018)