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In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer’s disease

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dc.contributor.authorMartínez-Rodriguez, Pedro
dc.contributor.authorHenarejos Escudero, Paula
dc.contributor.authorHernández García, Samanta
dc.contributor.authorGandía Herrero, Fernando
dc.contributor.authorSánchez Ferrer, Álvaro
dc.contributor.departmentBioquímica y Biología Molecular Aes
dc.coverage.temporal2024es
dc.date.accessioned2025-05-08T06:02:32Z
dc.date.available2025-05-08T06:02:32Z
dc.date.issued2024-07-24
dc.description© 2024 The Author(s). This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/. This document is the Published version of a Published Work that appeared in final form in Food Frontiers. To access the final edited and published work see https://doi.org/10.1002/fft2.453es
dc.description.abstractAnti-amyloidogenic properties of plant pigments betalains as potential nutraceuticals against Alzheimer’s disease have been screened using 24 pure molecules. Twenty-two betalains reduced amyloid aggregation in vitro, eight of them up to 100%, with IC 50values in the micromolar range. Atomic force and transmission electron microscopy images showed the typical fibrils associated with Alzheimer’s disease and how beta-lains avoid its formation. Neuroprotection after ingestion was supported by in vivo experiments with Caenorhabditis elegans. Indoline-betacyanin was the most effective molecule by significantly improving the chemotactic behavior of the CL2355 strain,a model of Alzheimer’s disease. Furthermore, in-depth molecular docking analyses revealed that the pigments interact with the N-terminal region of the amyloid pep-tide. This work is the most comprehensive study in the field and provides in vitro, in vivo, and in silico evidence for the use of betalains as nutraceuticals of relevance in theprevention of Alzheimer’s diseasees
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.citationFood Frontiers. 2024 5:2137–2154
dc.identifier.doihttps://doi.org/10.1002/fft2.453
dc.identifier.issnElectronic: 2643-8429
dc.identifier.urihttp://hdl.handle.net/10201/154100
dc.languageenges
dc.publisherWiley
dc.relationMinisterio deCienciaeInnovación, Grant/AwardNumber:PID2021-122896NBI00(MCIAEI/10.13039/501100011033/FEDER, UE); FundaciónSéneca,Grant/AwardNumber: 21587/FPI/21es
dc.relation.publisherversionhttps://iadns.onlinelibrary.wiley.com/doi/10.1002/fft2.453
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAlzheimer’s disease (AD)es
dc.subjectBetalainses
dc.subjectBioactive pigmentses
dc.subjectCaenorhabditis eleganses
dc.subjectNeuroprotectiones
dc.subjectNutraceuticalses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleIn vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer’s diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationdb7a1a52-fec7-48eb-91e0-abe5e715b483
relation.isAuthorOfPublicationaa6ca3f7-ee95-4c3b-b93d-82bbb7c57dd3
relation.isAuthorOfPublication.latestForDiscoverydb7a1a52-fec7-48eb-91e0-abe5e715b483
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