Publication: lnhibited differentiation of Langerhans cells in the rat epidermis upon systemic treatment with cyclosporin A
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Date
2001
Authors
Borghi-Cirri, M.B. ; Riccardi-Arbi, R. ; Bacci, S. ; Mori, M. ; Pimpinelli, N. ; Romagnoli, P. ; Filipponi, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The immunosuppressant drug cyclosporin A
(CsA) is known to cause reduction in number, DNA
synthesis and function of Langerhans cells (LC). Since
also the differentiation of LC is known to be hampered
in conditions of acquired immunodeficiency not due to
drugs, we investigated whether this occurs with CsA.
Rats were injected subcutaneously with CsA (5, 10 and
50 mg.kg-l.d-l) for three weeks; the skin was analyzed
by Ia immunohistochemistry and by electron
microscopy. Epidermal immunolabeled cells were
1553.5 (mean I SEM) per 100 basa1 keratinocytes in
untreated controls and 8.7511.3, 4.7551.0 and 1.751.2
upon increasing doses of CsA (pe0.01). By electron
microscopy, monocytoid cells with deep invaginations of
the plasma membrane and roundish LC poor in Birbeck
granules appeared in the epidermis upon treatment. The
results suggest that CsA inhibits the differentiation of
LC precursors in the epidermis and that this can in part
explain the selective increase in the risk of skin vira1
disease and cancer in chronically treated patients.
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