Publication: Short-term exposure of mice to gasoline vapor increases the metallothionein expression in the brain, lungs and kidney
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Date
2007
Authors
Grebic, Damir ; Jakovac, Hrvoje ; Mrakovcic-Sutic, Ines ; Tomac, J. ; Bulog, A. ; Micovic, V. ; Radosevic-Stasic, Biserka
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Environmental airborne pollution has been
repeatedly shown to affect multiple aspects of brain and
cardiopulmonary function, leading to cognitive and
behavioral changes and to the pronounced inflammatory
response in the respiratory airways. Since in the cellular
defense system the important role might have stress
proteins-metallothionein (MT)-I and MT-II, which are
involved in sequestration and dispersal of metal ions,
regulation of the biosynthesis and activities of zincdependent
transcription factors, as well as in cellular
protection from reactive oxygen species, genotoxicity
and apoptosis, in this study we investigated their
expression in the brain, lungs and kidney, following
intermittent exposure of mice to gasoline vapor. Control
groups consisted of intact mice and of those closed in the
metabolic chamber and ventilated with fresh air. The
data obtained by immunohistochemistry showed that
gasoline inhalation markedly upregulated the MTs
expression in tissues which were directly or indirectly
exposed to toxic components, significantly increasing
the number of MT I+II positive cells in CNS (the
entorhinal cortex, ependymal cells, astroglial cells in
subventricular zone and inside the brain parenchyma,
subgranular and CA1-CA3 zone of the dentate gyrus in
hippocampus and macrophages-like cells in perivascular
spaces), in the lungs (pneumocytes type I and type II)
and in the kidneys (parietal wall of Bowman capsule,
proximal and distal tubules). The data point to the
protective and growth-regulatory effects of MT I + II on
places of injuries, induced by inhalation of gasoline
vapor.
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