Publication: lmmunohistochemical characterization of transplantable rat squamous cell carcinoma (FF-6) in skin and thymus
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Date
1993
Authors
Fujikura, Y. ; Inoue, T. ; Sawada, T. ; Tokuda, N. ; Fukumoto, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
FF-6 is a transplantable squamous cell
carcinoma which originally arose in the facial skin of a
DA rat. It was established after maintaining the tumor in
the subcutaneous tissue or peritoneal cavity of DA rats
conventionally for over 30 generations. When the
soybean-sized original FF-6 tumor was transplanted
subcutaneously, it became an oval, hard, whitish, solitary
and thumb-head-sized nodule within one month. After
intraperitoneal transplantation of FF-6, it formed many
nodules ranging from miliary to thumb-head size, which
adhered andlor metastasized to many abdominal organs.
When FF-6, cut into small pieces, was injected into the
lower lip, the tumor grew bigger in situ, and
metastasized to regional lymph nodes. Histologically,
FF-6 was characterized as a well-differentiated
squamous cell carcinoma, showing positive staining with
anti-keratin, anti-laminin, anti-collagen type IV, antifibronectin
and UB- 14 antibodies.
This transplantable tumor may be useful for
analyzing the mechanisms of proliferation and
metastasis of squamous cell carcinoma in vivo, and the
host defence mechanism in rats, as well as being a
suitable model of human squamous cell carcinoma.
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