Publication: Copper zinc and manganese superoxide dismutases in alcoholic liver disease: immunohistochemical quantitation
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Date
1996
Authors
Zhao, M. ; Matter, K. ; Laissue, J.A. ; Zimmermann, Astrid
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Alcohol damage to the liver can, among
other factors, be mediated through the action of toxic
oxygen radicals generated by ethanol. Major antioxidants
in the liver are copperlzinc and manganese
superoxide dismutases (CuIZn- and Mn-SODS). In order
to test whether SODS may be differentially expressed in
alcoholic liver disease (ALD), biopsies from 45 patients
with ALD were analyzed for qualitative and quantitative
immunoreactivity of CuIZn- and Mn-SOD in hepatocytes.
The overall amount of Cu/Zn-SOD reactivity was
significantly lower in ALD than in control biopsies,
whereas no difference was found for Mn-SOD. Staining
for both enzymes was decreased in ballooned
hepatocytes. Low Cu/Zn-SOD was correlated with
advanced lattice-like perisinusoidal fibrosis. In
hepatocytes forming cirrhotic nodules, SOD reactivity
was similar to that of control cells. The results suggest
that SODS may be differentially regulated in ALD, and
that Mn-SOD, an inducible enzyme, may be involved in
recovery and cell protection in ALD.
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