Forensic avaluation and population genetic study of KIR2DS4 insertion/deletion polymorphisms in a Spanish population

Bolarín, Jose Miguel; Pérez Cárceles, M. Dolores; Luna, Aurelio; Minguela, Alfredo; Muro, Manuel; Legez Pérez, Isabel

Publication:
Forensic avaluation and population genetic study of KIR2DS4 insertion/deletion polymorphisms in a Spanish population

dc.contributor.author	Bolarín, Jose Miguel
dc.contributor.author	Pérez Cárceles, M. Dolores
dc.contributor.author	Luna, Aurelio
dc.contributor.author	Minguela, Alfredo
dc.contributor.author	Muro, Manuel
dc.contributor.author	Legez Pérez, Isabel
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2024-07-12T10:56:52Z
dc.date.available	2024-07-12T10:56:52Z
dc.date.issued	2021-06
dc.description	© 2020 Romanian Society of Legal Medicine. This document is the Published version of a Published Work that appeared in final form in Romanian Journal of Legal Medicine. To access the final edited and published work see https://doi.org/10.4323/rjlm.2020.419
dc.description.abstract	Polymorphisms (Indels) of insertion/deletion are a class of diallelic genetic markers resulting from a single mutation event and reflect the insertion or deletion of genomic DNA bases. The aim of this study was to analyze the distribution of the allelic variants of KIR2DS4 in the Spanish Caucasian population and compared it with other populations described in the literature. Genotyping of allelic variants of KIR2DS4 was performed by PCR-SSO in 127 healthy Spanish Caucasian individuals and were subsequently compared with 26 different world populations. A frequency of KIR2DS4-full (36.2%) allelic variants was found in the Spanish population, similar to those found European populations, but different and higher frequency in South and Central America and the Caribbean, Saudi Arabia, Sub-Saharan African as well as Hong Kong and Korean populations. A frequency of 77.2% of KIR2DS4-delected variant was found in Spanish population, while lower percentages were found in Sub-Saharan Africa, China, Hong Kong and Korea. No differences in the distribution of KIR2DS4 variants were observed between AA/BX KIR haplotypes and genotypes. In conclusion, our results enrich the Caucasian genetic information of the KIR2DS4 allelic variants between the Spanish Caucasian and other populations that could be useful in clinical, forensic and anthropological studies.	es
dc.format	application/pdf	es
dc.format.extent	10	es
dc.identifier.citation	Rom J Leg Med [28] 419-428 [2020]
dc.identifier.doi	https.//doi.org/10.4323/rjlm.2020.419
dc.identifier.issn	Print: 1221-8618
dc.identifier.issn	Electronic: 1844-8585
dc.identifier.uri	http://hdl.handle.net/10201/143033
dc.language	eng	es
dc.publisher	Romanian Society of Legal Medicine
dc.relation	Our work was possible thanks to the support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness. Grant Number PI15/01370 and P19/01194 and co-funding of the European Union with European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”. Isabel Legaz was a postdoctoral researcher from Sara Borrell program of the Spanish Health Ministry (ISCIII).	es
dc.relation.publisherversion	https://rjlm.ro/index.php/arhiv/839
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Anthropology	es
dc.subject	Forensic genetic	es
dc.subject	Forensic sciences	es
dc.subject	KIR genes	es
dc.subject	KIR2DS4 allele frequencies	es
dc.subject	Spanish population	es
dc.subject	Polymorphisms	es
dc.title	Forensic avaluation and population genetic study of KIR2DS4 insertion/deletion polymorphisms in a Spanish population	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es