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Primary biliary cirrhosis PBC, antigen-presenting cells differ in their distribution in early and late stage PBC and involve the ductal...

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dc.contributor.authorRontogianni, D.es
dc.contributor.authorGerber, H.es
dc.contributor.authorZimmermann, Astrid
dc.date.accessioned2011-02-01T09:17:52Z
dc.date.available2011-02-01T09:17:52Z
dc.date.issued1994
dc.description.abstractWe have studied the distribution patterns of antigen-presenting cells (APCs) in different stages of primary biliary cirrhosis (PBC). 58% of cases with early PBC (stages I and 11) exhibited dendritic APCs (S-loo+, HLA-DR+, KiMlp+) in bile duct epithelia. In contrast, APCs, were not detected in ductular proliferations occurring in late PBC (stages I11 and IV), but occurred in portal tracts and piecemeal necroses. There was a correlation between the presence of APCs and HLA-DR expression in bile ducts but, in contrast to former studies. we noted a heterogeneous ductal HLA expression. These observations support the hypothesis that: 1) APC distribution in PBC may change as a function of stage, involving hepatic parenchyma in late PBC; 2) ductular epithelia may not represent a target for immune attack, because APCs do not accumulate in these structures; and 3) HLA expression in bile ducts may be heterogeneous, suggesting one mechanism why bile duct destruction in PBC does not take place in a synchronous way.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18485
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAntigen presenting cellses
dc.subjectPrimary biliary cirrhosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titlePrimary biliary cirrhosis PBC, antigen-presenting cells differ in their distribution in early and late stage PBC and involve the ductal...es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 9, nº 2 (1994)