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Histopathological features of the gastroesophageal junction: an Eastern view

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dc.contributor.authorKim, Ahrong
dc.contributor.authorShin, Nari
dc.contributor.authorLee, Hyung-Jeong
dc.contributor.authorJo, Hong-Jae
dc.contributor.authorKim, Joo-Yeon
dc.contributor.authorKim, Young-Keum
dc.contributor.authorPark, Do Youn
dc.contributor.authorI, Hoseok
dc.contributor.authorKim, Gwang Ha
dc.coverage.spatialRepublica de Coreaes
dc.date.accessioned2020-09-18T08:12:15Z
dc.date.available2020-09-18T08:12:15Z
dc.date.issued2015
dc.description.abstractThe definition and features of the gastroesophageal junction (GEJ) and the histopathologic features of the cardiac mucosa remain controversial. Most reports originate from western countries, which have different prevalence of GEJ adenocarcinoma and gastroesophageal reflux disease (GERD) compared to eastern countries. Therefore, we investigated GEJ anatomic and histopathologic features by histological mapping in 30 esophagogastrectomy specimens of middle and lower esophageal squamous cell carcinoma. We measured the lengths of the cardiac mucosa, oxyntocardiac mucosa, and esophageal cardiactype glands. We assessed the presence of intestinal metaplasia, pancreatic acinar cells, Brunner’s-like glands, and submucosal esophageal gland beneath cardiac mucosa and the relationship of these features with age and the circumferential location of cardiac mucosa. The lengths of cardiac mucosa and esophageal cardiac-type glands significantly increased with age (<63 years, 2767.86±734.95 µm vs. ≥63 years, 5453.12±839.52 µm, P=0.025 and <63 years, 1151.78±452.81 µm vs. ≥63 years, 2273.44±321.58 µm, P=0.049, respectively) and the presence of circumferential cardiac mucosa (+, 5731.25±721.57 vs. −, 2625.00±356.00 µm, P=0.007; +, 2425.00±326.13 µm vs. −, 400.00±204.80 µm, P<0.0001 respectively). The presence of intestinal metaplasia and irregular GEJ increased with age and the circumferential location ofcardiac mucosa. The presence of esophageal submucosal glands beneath the cardiac mucosa, pancreatic acinar cells, and Brunner-like glands were seen in 8/30 (26.7%), 15/30 (50%), and 14/30 (46.7%) cases, respectively. These data indirectly suggest that cardiac mucosa originated from the distal esophagus and that the presence of cardiac mucosa may indicate GERD, in accordance with data from Western countries.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 6, (2015)
dc.identifier.doi10.14670/HH-30.689
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96122
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGastroesophageal junctiones
dc.subjectCardiac mucosaes
dc.subjectIntestinal metaplasiaes
dc.subjectEsophageal cardiac-type glandses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHistopathological features of the gastroesophageal junction: an Eastern viewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº6 (2015)