Publication: Grow2: The HIF system, energy homeostasis and the cell cycle
Authors
Moniz, Sónia ; Biddlestone, John ; Rocha, Sónia
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell cycle progression is an energy
demanding process and requires fine-tuned metabolic
regulation. Cells must overcome an energy restriction
checkpoint before becoming committed to progress
through the cell cycle. Aerobic organisms need oxygen
for the metabolic conversion of nutrients into energy. As
such, environmental oxygen is a critical signalling
molecule regulating cell fate. The Hypoxia Inducible
Factors (HIFs) are a family of transcription factors that
respond to changes in environmental oxygen and cell
energy and coordinate a transcriptional program which
forms an important part of the cellular response to a
hostile environment. A significant proportion of HIFdependent
transcriptional target genes, code for proteins
that are involved in energy homeostasis. In this review
we discuss the role of the HIF system in the regulation
of energy homeostasis in response to changes in
environmental oxygen and the impact on cell cycle
control, and address the implications of the deregulation
of this effect in cancer.
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Citation
Histology and Histopathology, vol. 29, nº 5, (2014)
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