Publication: The SH2 and SH3 adapter Nck:
a two-gene family and a linker between
tyrosine kinases and multiple signaling networks
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Date
2000
Authors
Li, W. ; She, H.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
SH2 and SH3 adapter proteins connect cell
surface tyrosine kinases to intracellular signaling
networks. For instance, the SH3-SH2-SH3 adapter Grb2
links receptor tyrosine kinases to the Ras pathway. Nck,
composed of three SH3 domains and one SH2 domain,
represents a two-gene (alpha and beta) family in
mammals. Ncka and Nck13 are expressed in the same
cells and appear to have distinct signaling specificity.
Studies show that Nck plays a role in cell mitogenesis
and morphogenesis. The former uses Ras-dependent and
Ras-independent pathways. The latter appears to
coordinate with the Cdc42/Rac>PAK lIWASp>actin
cytoskeleton pathway. Understanding the specificity of
Ncka and NckB signal transduction will provide answers
for the previously often conflicting observations.
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Citation
Histology and Histopathology, Vol. 15, n.º 3 (2000)
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