Publication: Expression of plakophilin 3 in diffuse malignant pleural mesothelioma
Authors
Mašić, Silvija ; Brčić, Luka ; Krušlin, Božo ; Pigac, Biserka ; Stančić Rokotov, Dinko ; Jakopović, Marko ; Seiwerth, Sven
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670-11-996
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info:eu-repo/semantics/article
Description
Abstract
Diffuse malignant pleural mesothelioma
(DMPM) is the most common primary malignant pleural
neoplasm still posing major diagnostic, prognostic and
therapeutic challenges. Plakophilins are structural
proteins considered to be important for cell stability and
adhesion in both tumor and normal tissues. Plakophilin 3
is a protein present in desmosomes of stratified and
simple epithelia of normal tissues with presence in
malignant cells of various tumors where it participates in
the process of tumorigenesis. The aim of this study was
to investigate the expression of plakophilin 3 protein in
DMPM, but also to study its prognostic significance and
relation to histologically accessible parameters of
aggressive growth. Archival samples of tissue with
established diagnosis of DMPM and samples of normal
pleural tissue were used. Tumor samples were classified
into three histological types of DMPM (epithelioid,
sarcomatoid and biphasic). Additional subclassification
of epithelioid mesotheliomas into nine patterns based on
the prevalent histological component of the tumor was
then performed. After immunohistochemical staining,
cytoplasmic and membrane immunopositivity of tumor
cells was assesed by scoring the intensity of the staining
from 0 (no staining) to 4 (very strong staining).
Prognostic value and expression of plakophilin 3 with
consideration to histologically estimated aggression in
tumor growth were then statistically analyzed using nonparametric tests. The results demonstrated higher level
of plakophilin 3 expression in tumor samples with
histologically more aggressive tumor growth, but no
significant prognostic value. According to our study,
plakophilin 3 appears to be involved in tumor invasion
in malignant mesothelioma.
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Citation
Histology and Histopathology, Vol.33, nº9, (2018)
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