Publication: Assessment of anogenital distance as a diagnostic tool in polycystic ovary syndrome
Authors
Hernández-Peñalver, Ana I. ; Sánchez-Ferrer, María L. ; Mendiola, Jaime ; AdoamneI, Evdochia ; Prieto-Sánchez, María T. ; Corbalán-Biyang, Shiana ; Carmona-Barnosi, Ana ; Nieto, Aníbal ; Torres-Cantero, Alberto M.
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.rbmo.2018.08.020
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info:eu-repo/semantics/article
Description
©<2018>. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the, Accepted, version of a Published Work that appeared in final form in Reproductive BioMedicine Online. To access the final edited and published work see: https://doi.org/10.1016/j.rbmo.2018.08.020
Abstract
Is anogenital distance (AGD) a useful clinical tool for predicting polycystic ovarian syndrome (PCOS) and its main National Institutes of Health (NIH) phenotypes? Case-control study conducted between September 2014 and May 2016 at the Department of Obstetrics and Gynecology of the University Clinical Hospital 'Virgen de la Arrixaca' in the Murcia region (south-eastern Spain). One hundred and twenty-six cases of PCOS and 159 controls without PCOS were included. AGD measurements were taken from the anterior clitoral surface to the upper verge of the anus (AGDAC), and from the posterior fourchette to the upper verge of the anus (AGDAF). Parametric and non-parametric tests and receiver operating characteristic (ROC) curves were used to assess associations between AGD and the presence of PCOS and its phenotypes. AGDAC, but not AGDAF, was associated with PCOS and all its phenotypes (P-values < 0.001 to 0.048). The highest area under the curve (0.62; 95% confidence interval 0.55 to 0.71) was obtained for all PCOS with AGDAC with a sensitivity and specificity of 50.0% and 73.0%, and positive and negative predictive value of 59.0% and 64.4%, respectively. AGDAC could moderately discriminate the presence of PCOS and may be a useful clinical tool.
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Citation
Reproductive Biomedicine Online. 2018 Dec 37(6):741-749
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/