Publication: The role of xanthine oxidase in
Authors
Frederiks, W.M. ; Bosch, K.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Oxygen radicals have been proposed to be
involved in the induction of liver cell damage during
reperfusion after ischemia. The role of xanthine oxidase
in this process and the potential of the antioxidant
system have been studied in a model of in vivo ischemia
of rat liver followed by 1 h reperfusion by the use of
enzyme histochemistry. Based on decreased lactate
dehydrogenase activity in certain areas of liver
parenchyma, cell damage could already be detected at
1 h reperfusion after ischemia. Incubations performed on
serial sections showed that the same areas contained
decreased activities of xanthine oxidoreductase, xanthine
oxidase, catalase and glucose-6-phosphate dehydrogenase.
Some individual cells in the undamaged liver
parenchyma expressed a very high glucose-6-phosphate
dehydrogenase, which suggests that these cells have a
good defence against oxidative stress. It is concluded
that oxygen radicals derived from xanthine oxidase do
not play a decisive role in the induction of cell damage
immediately at reperfusion after ischemia. However, it
cannot be excluded that xanthine oxidase present in the
blood stream can give rise to the development of
additional damage later on.
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