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Pore alterations of the endothelial lining of rat fenestrated intestinal capillaries exposed to acute stress

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dc.contributor.authorAosa, Taishi
dc.contributor.authorChiba, Seiichi
dc.contributor.authorKitamura, Hirokazu
dc.contributor.authorIna, Keisuke
dc.contributor.authorTatsukawa, Shuji
dc.contributor.authorMoriwaki, Chinatsu
dc.contributor.authorWei, Huixing
dc.contributor.authorGotoh, Koro
dc.contributor.authorMasaki, Takayuki
dc.contributor.authorKakuma, Tetsuya
dc.contributor.authorShibata, Hirotaka
dc.contributor.authorFujikura, Yoshihisa
dc.date.accessioned2021-07-29T08:55:40Z
dc.date.available2021-07-29T08:55:40Z
dc.date.issued2016
dc.description.abstractStress-induced inflammatory responses in the portal system are characterized by elevations in serum concentrations of interleukin-6 (IL-6) and endotoxins such as lipopolysaccharides (LPS). LPS translocation from the intestinal to the capillary lumen occurs via LPS endocytosis by the capillary endothelium. Because the capillary endothelium of the small intestinal submucosa is fenestrated, we determined the role of pore modifications within the fenestrated endothelium in relaying inflammatory stress responses in the portal vein. We evaluated changes in the diameter and density of endothelial pores of the lamina propria of intestinal villi induced by continuous light (CL) exposure for 48 h and the correlation between these changes and serum IL-6 concentration in the portal vein in a rat model. We found significant increases in both the pore diameter and density, accompanied by a significant increase in portal IL-6 concentration; these changes were significantly attenuated by pretreatment with propranolol, a beta adrenergic receptor antagonist. In contrast, intravenous noradrenaline administration mimicked CL-induced modifications of the diameter and density of pores and the elevation of portal vein IL-6 concentration. These findings suggested that stress-induced inflammatory responses in the portal system may be a part of the modifications of the endothelial pores triggered by sympathetic activation.es
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dc.format.extent11es
dc.identifier.citationHistology and histopathology, Vol.31, nÂş7 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-716
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/111441
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCapillary porees
dc.subjectFenestrated capillaryes
dc.subjectStresses
dc.subjectInterleukin-6es
dc.subjectIntestinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titlePore alterations of the endothelial lining of rat fenestrated intestinal capillaries exposed to acute stresses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nÂş7 (2016)