Publication: Staining patterns of keratins in the human urinary tract
Authors
Alonso, Angélica ; Ikinger, Uwe ; Kartenbeck, Jürgen
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The keratins, members of the intermediate
filament family, are characteristically expressed in
epithelial cells. In the various types of epithelia, the
keratin expression pattern is characterized by cell-type
specific combinations of the keratin isotypes with a plain
pattern in monolayered (simple) epithelia and more
complex patterns in stratified and pseudostratified
epithelia. Here we demonstrate that the transitional
epithelium of the human urinary tract holds an
exceptional position between the pseudostratified and
stratified epithelia. We show that the simple epithelia
keratins 7, 8, 18 and 19 are expressed throughout the
whole epithelium as known from pseudostratified
epithelia. In addition, we demonstrate expression of
keratins 5, 14 and 17, otherwise present in basal cells of
multilayered epithelia, and keratins 4 and 13, present in
suprabasal areas of non cornified multilayered epithelia.
Moreover, we report differences in expression in the
various morphological parts of the urinary tract which
might be related to their specific functions. Keratin 20, a
typical component of the simple epithelia of the
digestive tract, is present in bladder and ureter but not in
the renal pelvis. Keratin 6, typical for stratified epithelia,
is found only in parts of the renal pelvis.
We further show that changes in keratin pattern
occur during the development from embryonic to adult
bladder urothelium. In contrast to adult tissue, the simple
type keratins 7, 8 and 18 are not synthesized in basal
embryonic cells. Further, keratin 20, present in cells
facing the bladder lumen in adult urothelium, is
expressed in all but the basal cells in embryonic bladder.
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