Microanatomy of lymphocyte-endothelial interactions
at the high endothelial venules of lymph nodes

Tohya, Kazuo; Umemoto, Eiji; Miyasaka, Masayuki

Publication:
Microanatomy of lymphocyte-endothelial interactions at the high endothelial venules of lymph nodes

dc.contributor.author	Tohya, Kazuo
dc.contributor.author	Umemoto, Eiji
dc.contributor.author	Miyasaka, Masayuki
dc.date.accessioned	2015-10-06T15:34:51Z
dc.date.available	2015-10-06T15:34:51Z
dc.date.issued	2010
dc.description.abstract	Lymphocyte trafficking into lymph nodes and Peyer’s patches is mediated primarily by specifically differentiated venules, called high endothelial venules (HEVs), located in the tissue parenchyma. HEVs have a unique morphology and phenotype, which enables them to interact with circulating lymphocytes efficiently. That is, the HEV endothelial cells have a tall and plump appearance, and constitutively express multiple adhesion molecules and chemokines on their surface. These molecules can interact with cognate receptors on circulating lymphocytes, thereby mediating the stepwise and sequential lymphocyte adhesion and transendothelial migration (TEM) at the HEV endothelial luminal surface. This review summarizes the fine morphological aspects of the unique HEV endothelial cells, with special reference to the spatial distribution of the adhesion molecules and chemokines that regulate lymphocyte migration.	es
dc.format	application/pdf	es
dc.format.extent	14	es
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/46513
dc.language	eng	es
dc.publisher	Murcia: F. Hernández	es
dc.relation.ispartof	Histology and histopathology, Vol. 25, nº 6 (2010)	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Lymphocyte migration	es
dc.subject	Chemokine	es
dc.subject.other	61 - Medicina	es
dc.title	Microanatomy of lymphocyte-endothelial interactions at the high endothelial venules of lymph nodes	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es