Publication:
Memory B cells and CD27

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Memory B cells and CD27.pdf(1.73 MB)
Date
2000
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Authors
Agematsu, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Following antigen activation in germinal centers, B cells develop into memory B cells or plasma cells. Triggering via B-cell immunoglobulin receptors by antigens, cytokines and direct cell-to-cell contact by B and T cells plays an important role in the B cell differentiation into memory or plasma cells. Adult human peripheral blood B cells are separated into three subtypes by the expression of IgD and CD27, which belong to the tumor necrosis factor receptor (TNFR) family: IgD+ CD27- naive B cells, IgDt CD27t and IgD- CD27t B cells. CD27+ B cells are larger cells with abundant cytoplasm carrying somatic hypermutation, and have an ability to produce immunoglobulin, indicating that CD27 is a memory marker of B cells. The ligation of CD27 yields crucial signals that positively control the entry of B cells into the pathway to plasma cells. We review observations on subpopulations and differentiation of mature B-cells by TIB cell interaction via CD27lCD70 as compared with CD40lCD154 interaction, and discuss about memory B cells.
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Plasma cell , Memory B cells
Citation
URI
http://hdl.handle.net/10201/19297
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Histology and histopathology Vol.15, nº 2 (2000)
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