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The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice

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dc.contributor.authorPiotrowska, Katarzyna
dc.contributor.authorBorkowska, Sylwia J.
dc.contributor.authorWiszniewska, Barbara
dc.contributor.authorLaszczyńska, Maria
dc.contributor.authorSłuczanowska-Głąbowska, Sylwia
dc.contributor.authorHavens, Aaron M.
dc.contributor.authorKopchick, John J.
dc.contributor.authorBartke, Andrzej
dc.contributor.authorTaichman, Russel S.
dc.contributor.authorKucia, Magda
dc.contributor.authorRatajczak, Mariusz Z.
dc.date.accessioned2018-09-10T14:49:14Z
dc.date.available2018-09-10T14:49:14Z
dc.date.issued2013
dc.description.abstractIt is well known that somatotrophic/insulin signaling affects lifespan in experimental animals. To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on the morphology of major organs, we analyzed lung, heart, liver, kidney, bone marrow, and spleen isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice (with low circulating plasma levels of IGF-1) and 6-month-old bovine growth hormone transgenic (bGHTg) mice (with high circulating plasma levels of IGF-1). The ages of the two mutant strains employed in our studies were selected based on their overall ~50% survival (Laron dwarf mice live up to ~4 years and bGHTg mice up to ~1 year). Morphological analysis of the organs of long-living 2-year-old Laron dwarf mice revealed a lower biological age for their organs compared with normal littermates, with more brown adipose tissue (BAT) surrounding the main body organs, lower levels of steatosis in liver, and a lower incidence of leukocyte infiltration in different organs. By contrast, the organs of 6-month-old, short-living bGHTg mice displayed several abnormalities in liver and kidney and a reduced content of BAT around vital organs.es
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 10 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/60959
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAginges
dc.subjectBrown adipose tissuees
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleThe effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº10 (2013)