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Is maternal use of Paracetamol during pregnancy associated with anogenital distance in male newborns? The results from the NELA Birth Cohort

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dc.contributor.authorNavarro Lafuente, Fuensanta
dc.contributor.authorArense Gonzalo, Julián Jesús
dc.contributor.authorAdoamnei, Evdochia
dc.contributor.authorPrieto Sánchez, María Teresa
dc.contributor.authorSánchez Ferrer, María Luisa
dc.contributor.authorGarcía-Marcos Álvarez, Luis Vicente
dc.contributor.authorMorales Bartolomé, Eva
dc.contributor.authorMendiola Olivares, Jaime
dc.contributor.authorTorres Cantero, Alberto Manuel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2025-12-05T11:16:04Z
dc.date.available2025-12-05T11:16:04Z
dc.date.copyright© 2021 by the authors
dc.date.issued2021-06-11
dc.description.abstractParacetamol is the one of the most commonly used medications during pregnancy. However, its potential antiandrogenic effect has been suggested. The objective of this study was to evaluate associations between maternal paracetamol use during pregnancy and anogenital distance (AGD) in male newborns from a Spanish birth cohort. The study included two hundred and seventy-seven mother-male child pairs with self-reported paracetamol use and frequency during each trimester of pregnancy. AGD measurements were taken employing standardized methods. The associations between maternal paracetamol use and AGD measures were evaluated using linear regression models, adjusting for potential confounders and covariates. Overall, 61.7% of pregnant women consumed paracetamol at any time of pregnancy with an average of 9.43 (SD = 15.33) days throughout pregnancy. No associations between the maternal use of paracetamol or its frequency and AGD measures among different trimesters or during the whole pregnancy were found in the adjusted final models. A non-differential misclassification error may have occurred—the recall of paracetamol intake independent of AGD measurements—introducing bias towards the null hypothesis. Nevertheless, the current evidence suggests that paracetamol might have a potential antiandrogenic effect especially in the early stages of fetal development. Thus, it would be highly recommendable to pursue further studies to elucidate the potential effects of paracetamol in human perinatal health and its use among pregnant women.
dc.formatapplication/pdf
dc.format.extent11
dc.identifier.citationInternational Journal of Environmental Research and Public Health, 2021, Vol. 18, Issue 12 : 6338
dc.identifier.doihttps://doi.org/10.3390/ijerph18126338
dc.identifier.eissn1660-4601
dc.identifier.issn1661-7827
dc.identifier.urihttp://hdl.handle.net/10201/177950
dc.languageeng
dc.publisherMDPI
dc.relationWe acknowledge all funding sources for the NELA birth cohort study: Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities (Grants: MS14/00046; CP14/00046; PIE15/00051; PI16/00422; FI17/00086; PI19/00863), Fondos FEDER, Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (Grant: 20877/PI/18). FN-L is a recipient of a FPU predoctoral fellowship from the Spanish Ministry of Science and Innovation (FPU18/01990).
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/12/6338
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAcetaminophen
dc.subjectAnogenital distance
dc.subjectAGD
dc.subjectEndocrine disruptors
dc.subjectPregnancy
dc.subjectParacetamol
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleIs maternal use of Paracetamol during pregnancy associated with anogenital distance in male newborns? The results from the NELA Birth Cohort
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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