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The role of claudin-6 in chromophobe renal cell carcinoma

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dc.contributor.authorErlmeier, Franziska
dc.contributor.authorZschäbitz, Stefanie
dc.contributor.authorMikuteit, Marie
dc.contributor.authorAutenrieth, Michael
dc.contributor.authorWeichert, Wilko
dc.contributor.authorHartmann, Arndt
dc.contributor.authorSteffens, Sandra
dc.date.accessioned2023-03-29T11:31:52Z
dc.date.available2023-03-29T11:31:52Z
dc.date.issued2023
dc.description.abstractBackground. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohistochemistry. Results. 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6- compared to CLDN6+ tumors (87.0% versus 62.5%; p=0.174). Conclusion. In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.es
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dc.format.extent5es
dc.identifier.citationHistology and Histopathology, Vol.38, nº4, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-520
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129708
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRenal Cell Carcinomaes
dc.subjectClaudin-6es
dc.subjectChromophobe histologyes
dc.subjectSurvivales
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe role of claudin-6 in chromophobe renal cell carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº4 (2023)