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Etiology of the developing eye in myelencephalic blebs (my) mice

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dc.contributor.authorCenter, Elizabeth M.es
dc.contributor.authorPolizotto, René S.es
dc.date.accessioned2011-02-01T08:46:50Z
dc.date.available2011-02-01T08:46:50Z
dc.date.issued1992
dc.description.abstractThe etiology of the eye defects in myelencephalic blebs (my) mutant mice has been poorly understood for almost seventy years. Embryos from 9 to 14 M days of gestation were subjected to Alcian blue 8GX staining for acidic glycosaminoglycan deposition in basement membrane structures of the developing eye in my stock and control specimens. In addition 12 day embryos were subjected to avidinbiotin- peroxidase labelling for laminin. At 9 - 9 M days of gestation more Alcian blue positive extracellular matrix was found in the region between the optic vesicle and the overlying putative lens ectoderm in the my stock embryos. By 12 days, there was an irregular and lesser amount of deposition of glycosaminoglycans in the len's capsule and in the «inner lirniting membrane~ of the presumptive neural retina; however, the deposition of laminin appeared to be greater in the inner lirniting membrane of the my eye. By 14 days, the damage to the eye in the my embryos can be quite extensive, and the deposition of glycosaminoglycans was very meager in this situation. It appears that irregular deposition of glycosaminoglycans in the extracellular matrix and possible increase in the amount of laminin in basement structures in my embryos indicate disruption of the normal histochemistry involved in the development of the eye. Altered histochemistry may in turn indicate changes in permeability between cells of the developing tissues which result in the blebbing.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18301
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBlebses
dc.subjectEyees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEtiology of the developing eye in myelencephalic blebs (my) micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 7, nº 2 (1992)