Publication: Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification
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Date
2008
Authors
Ohtsuki, Yuji ; Yamanaka, Akira ; Ohyama, Hideki ; Yamada, Eiji ; Terada, Nobuyuki ; Fujita, Jiro ; Lee, Gang-Hong ; Furihata, Mutsuo
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Diffuse pulmonary ossification is a rare
condition. We examined three cases of it in Japan, and
attempted histochemically to stain for deposition of
aluminum and iron in bony tissues. The patients were all
female, and in their mid-twenties, mid- eighties, and
later teen years. One of the patients had been exposed to
heavy metals in her work involving heavy-metal
analyses for 18 months. Aluminum staining and Berlin
blue staining for iron were performed with dewaxed,
undecalcified sections of pulmonary tissues from these
three cases.
Interestingly, all pulmonary bony tissues from the
three cases examined exhibited linear regions of both
aluminum and iron deposition in the calcifying fronts or
the cement lines of bones. The patient exposed to heavy
metals exhibited the most severe aluminum and iron
deposition, and also exhibited positive reaction for both
aluminum and iron in elastic fibers of blood vessels.
Foreign body granulomas with multinucleated giant cells
exhibiting elastophagia were also found in this case.
This phenomenon, “endogenous pneumoconiosis”,
appeared to have been the cause of pulmonary
hemorrhage in this case, resulting in focal heavy
hemosiderosis. It is of great interest that identical
patterns of aluminum and iron deposition in
hemodialysis patients were found in these three cases,
This is the first report on histochemical
demonstration of aluminum and iron deposition in
diffuse pulmonary ossification, and detailed analysis of
additional cases is needed.
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