Publication: Microencephaly and microphthalmia in rat fetuses by busulfan
Authors
Furukawa, S. ; Usuda, K. ; Abe, M. ; Ogawa, I.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Microencephaly and microphthalmia in the
embryos/fetuses from rats exposed to busulfan were
histopathologically examined. Busulfan was
intraperitoneally administered at 10 mg/kg on gestation
days (Days) 12, 13 and 14, and then embryos/fetuses
were harvested on Days 14.5, 15, 16 and 21. In the
treated group on Day 21, all fetuses were small with
reduced body weight, with microencephaly and
microphthalmia. On Days 14.5, 15 and 16, apoptotic
cells were increased in the neuroepithelium and the
neural retina with a width reduction and a decrease in
cell density, and the lens epithelial cells
histopathologically. Mitotic inhibition was observed in
the neuroepithelium, neural retina and equatorial zone of
the lens. On Day 21, the cerebral cortex and the retina
became markedly thinner. The lens fibers showed
swollen, fragmentary and vacuolar formation in the
cranial portion accompanied with small lens sizes. The
anti-proliferative effects of busulfan brings about a lack
of cell populations required for the normal
organogenesis of the brain and eye, and leads to
microencephaly and microphthalmia, featuring
hypoplasia of cerebrum and hypoplasia of retina and lens
with cataract, respectively
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.