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Second primary molar hypomineralisation and drugs used during pregnancy and infancy. a systematic review

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dc.contributor.authorSerna Muñoz, Clara
dc.contributor.authorOrtiz Ruiz, Antonio José
dc.contributor.authorPérez Silva, Amparo
dc.contributor.authorBravo González, Luis Alberto
dc.contributor.authorVicente, Ascensión
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-06-21T07:28:26Z
dc.date.available2024-06-21T07:28:26Z
dc.date.issued2019-07-16
dc.description© Springer-Verlag GmbH Germany, part of Springer Nature 2019. This document is the Published version of a Published Work that appeared in final form in Clinical Oral Investigations. To access the final edited and published work see https://doi.org/10.1007/s00784-019-03007-7
dc.description.abstractObjectives Hypomineralised second primary molars (HSPM) are due to idiopathic hypomineralisation that affects from 1- to 4-s primary molars, and its aetiology remains unclear. Our objective was to systematically review studies in which the investigators had studied the association between HSPM and drug use during pregnancy and the first year of life. Materials and methods A systematic search for publications until July 2018 was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. No restrictions were placed on year of publication. The PECO Question was as follows: P, children exposed to drugs during pregnancy and the first year of life; E, drugs to which mothers, during pregnancy and their offspring were exposed; C, control groups from studies with the same characteristics not exposed to drugs during pregnancy and the first year of life; and O, relationship between drug exposure during pregnancy and the first year of life and HSPM. Two reviewers extracted the data and assessed the risk of bias using the Newcastle-Ottawa Scale criteria. Results We initially identified 986 articles, or which seven were selected for review: two case-control studies, one cross-sectional studies and four cohort studies. Four studies reported data on drug consumption during pregnancy and four investigated drug use during the first year of life and the occurrence of enamel defects in primary dentition. Conclusions There is no clear evidence that the use of drugs during pregnancy and during the first year of life is associated with HSPM. Further well-designed prospective studies are needed.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationClinical Oral Investigations, (2020) 24:1287–1297
dc.identifier.doihttps://doi.org/10.1007/s00784-019-03007-7
dc.identifier.issnPrint: 1432-6981
dc.identifier.issnElectronic: 1436-3771
dc.identifier.urihttp://hdl.handle.net/10201/142497
dc.languageenges
dc.publisherSpringeres
dc.relationSin financiación externa a la Universidades
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHypominerali sedsecond primary molarses
dc.subjectDeciduous mola rhypomineralisationes
dc.subjectDrugses
dc.titleSecond primary molar hypomineralisation and drugs used during pregnancy and infancy. a systematic reviewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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