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Signaling molecules and pathways involved in MSC tumor tropism

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dc.contributor.authorHo, Ivy AW
dc.contributor.authorLam, Paula YP
dc.date.accessioned2018-10-04T14:28:59Z
dc.date.available2018-10-04T14:28:59Z
dc.date.issued2013
dc.description.abstractHuman bone marrow is a reservoir containing cells with different self-renewal capabilities, such as mesenchymal stem cells (MSC) and hematopoeitic stem cells (HSC). MSC in particular have been increasingly used in preclinical and clinical treatment of tissue regenerative disorder. Understanding the molecular mechanisms underlying MSC homing and mobilization is critical to the design of rational cell therapy approaches. In this review, we will discuss the key molecular mechanisms that govern the homing of MSC to bone marrow, the mobilization of MSC to tumors and injured sites via circulation, and strategies that enhance MSC migration.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 11 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/61621
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMesenchymal stem cellses
dc.subjectMigrationes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleSignaling molecules and pathways involved in MSC tumor tropismes
dc.typeinfo:eu-repo/semantics/otheres
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº11 (2013)