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Rheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literature

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dc.contributor.authorSpina, Donatella
dc.contributor.authorAmbrosio, Maria Raffaella
dc.contributor.authorRocca, Bruno Jim
dc.contributor.authorDi Mari, Nicoletta
dc.contributor.authorOnorati, Mónica
dc.contributor.authorLuzzi, Luca
dc.contributor.authorMonciatti, Irene
dc.contributor.authorTosi, Piero
dc.date.accessioned2016-03-08T17:29:18Z
dc.date.available2016-03-08T17:29:18Z
dc.date.issued2011
dc.description.abstractAn association between rheumatoid arthritis (RA) and malignancies has been ascertained and patients with RA appear to be at higher risk of lymphoma and lung cancer. The higher risk of the latter malignancy may be related to rheumatoid interstitial lung disease and immunosuppressive therapies. Herein we illustrate the case of a 59-year-old male smoker affected by RA and treated with cortisone, methotrexate and TNF-α antagonists, who underwent right lower lobectomy for a nodular lesion. On microscopic examination, the lesion consisted of two distinct areas: a central area of fibrinoid necrosis, bordered by histiocytes in a palisaded arrangement, lymphocytes and a 0.4 cm thick peripheral area constituted by a combined small cell anaplastic carcinoma, adenocarcinoma and squamous cell carcinoma. The combination of three histotypes is very rare in such a small tumour. In our case, it may be hypothesized that synchronous, heterogeneous mutations occurred in different type of committed cells or in stem cells, due to the production of cytokines by RA nodule histiocytes and lymphocytes, which are contiguous to the carcinomatous area. Since few studies have evaluated the topographic correlation between tumors and rheumatoid lung lesions, further morphological and molecular studies are needed to clarify this association and the pathogenetic relationship between RA and cancer of the lung.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/48281
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 3 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRheumatoid arthritises
dc.subjectInterstitial pneumoniaes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleRheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literaturees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº3 (2011)