Publication: Interleukin 1 receptor antagonist (IL1RN) genetic
variations condition post-orthodontic external
root resorption in endodontically-treated teeth
Authors
Iglesias-Linares, Alejandro ; Yañez-Vico, Rosa Mª ; Ballesta-Mudarra, Sofía Ballesta-Mudarra ; Ortiz-Ariza, Estefanía ; Mendoza-Mendoza, Asunción ; Perea-Pérez, Evelio ; Moreno-Fernández, Ana Mª ; Solano-Reina, Enrique
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
y. External pical root resorption (EARR) is a
frequent iatrogenic problem following orthodontic
treatment in endodontically-treated teeth, about which
the literature reports substantial variability in postorthodontic
treatment EARR responses. The main focus
of the present study is to clarify whether variants in the
interleukin-1 receptor antagonist gene coding for the IL1ra
protein have a positive/negative influence on EARR
of endodontically-treated teeth. Ninety-three orthodontic
patients were genetically screened for a single nucleotide
polymorphism (SNP:rs419598) in the IL1 cluster. The
sample was classified into 2 groups: group 1 (affectedgroup)
showed radiographic EARR of more than 2mm;
group 2 (control-group), had no EARR or EARR≤ to
2mm following orthodontic treatment on root-filled
teeth. Logistic regression analysis was performed to
obtain an adjusted estimate between the SNPs studied
and EARR. Genotype distributions, allelic frequencies,
adjusted odds ratios (OR) and 95% confidence intervals
were also calculated. We found that subjects
homozygous [1/1(TT)] for the IL1RN gene [OR:10.85;
p=0.001;CI:95%] were at risk of EARR in root-filled
teeth. Genetic variants in the antagonist axis balance of
the IL1RN(rs419598) have a direct repercussion on the
predisposition to post-orthodontic EARR in root-filled
teeth. Variants in allele 1 of the interleukin-1 receptor
antagonist gene(rs419598) are associated(p=0.001**)
with an increased risk of suffering post-orthodontic
EARR in root-filled teeth.
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Citation
Histology and Histopathology, vol. 28, nº 6. (2013)
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