Publication: A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease?
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Date
2009
Authors
Slevin, M. ; Krupinski, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Native CRP (nCRP) is a pentameric
oligoprotein composed of identical 23 KDa subunits
which can be irreversibly dissociated to form free
subunits or monomeric CRP (mCRP). mCRP has a
reduced aqueous solubility and a tendency to aggregate
into matrix-like lattices in various tissues, in particular,
blood vessel walls. A dramatic increase in expression of
mCRP occurs in angiogenic blood vessels derived from
stroked brain regions, atherosclerotic arteries and active
vessels from other angiogenic diseases such as
Alzheimer’s. Furthermore, mCRP unlike the native
molecule is highly angiogenic to vascular endothelial
cells in vitro and therefore might impact on the processes
of vascularization and re-modelling thus affecting tissue
survival and development. In this mini-review, we will
discuss the differences in the biological properties
between nCRP and mCRP. We will provide a brief
historical background to the importance of nCRP as a
biomarker for cardiovascular disease. We will explain
the mechanisms of conversion of nCRP to its monomeric
form and describe evidence for the role of mCRP in
modulation of endothelial cell activation, promotion of
inflammatory status and thrombus formation in
cardio/cerebrovascular disease. Finally, we will provide
evidence for the accumulation of mCRP in angiogenic
microvessels from diseased tissue, and demonstrate its
highly pro-angiogenic capabilities. The discovery of the
existence of this tissue-associated, highly angiogenic
monomeric form of CRP capable of cellular binding and
intra-cellular signal transduction activation may help in
our understanding of the processes responsible for modulation of angiogenesis and inflammation in disease.
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