Publication: Autoradiographic localization of estrogen target cells in the spinal cord of the armadillo and baboon, a comparative study
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Date
1987
Authors
Weaker, Frank J. ; Sheridan, Peter J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The uptake and retention of radiolabeled
estradiol by the spinal cord were examined in the baboon
and the armadillo and compared to previous observations
in the rat. Four females of each species were injected
intracardially with 1.0-1.4 pg/kg body weight of %-
estradiol and two females, one baboon and one armadillo,
were injected with both labeled and 100-140 pg/kg body
weight of unlabeled estradiol. One hour after the
injections, the animals were killed and segments from the
cervical, thoracic, lumbar and sacral cord were removed
and processed for autoradiography. In the armadillo,
labeling of neuronal nuclei were noted in laminae I & I1
and in alpha motor neurons. In addition, nuclei of the
ependymal cells of the ventral portion of the central
canal in the cervical cord concentrated radioactivity. In
contrast, the baboon demonstrated only sporadic labeling
of neurons in lamina I1 in all levels of the spinal cord. The
comparison of our observations with that of the rat
suggest that estrogen mediated sensations are probably
coordinated at higher brain centers in the primate as
opposed to the more primitive mammals
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