Publication: Dual immune functions of IL-33 in inflammatory bowel disease.
Authors
Chen, Jie ; He, Yan ; Tu, Lei ; Duan, Lihua
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-149
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info:eu-repo/semantics/article
Description
Abstract
Interleukin-33 (IL-33) has emerged as a
critical regulator in a variety of diseases, including
inflammatory bowel disease (IBD). IL-33 can be
produced by various tissues and cells, and typically
induces Th2-type immune responses via binding to the
receptor ST2. In addition, accumulated data have shown
that IL-33 also plays a modulatory role in the function of
regulatory T cells (Tregs), B cells, and innate immune
cells such as macrophages and innate lymphoid cells
(ILCs). IBD, including Crohn’s disease and ulcerative
colitis, are characterized by aberrant immunological
responses leading to intestinal tissue injury and
destruction. Although IL-33 expression is increased in
IBD patients and correlates with the patients’ disease
activity index, mechanistic studies to date have
demonstrated both pathogenic and protective roles in
animal models of experimental colitis. In this review, we
will summarize the roles and mechanisms of IL-33 in
IBD, which is essential to understand the pathogenesis
of IBD and determine potential therapies.
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Citation
Histology and Histopathology Vol. 35, nÂş 2 (2020)
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