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Routine histopathology of septal myectomy for hypertrophic obstructive cardiomyopathy in a greek cohort

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dc.contributor.authorIoakeimidis, Nikolaos S.
dc.contributor.authorPitsis, Antonios
dc.contributor.authorNtelios, Dimitrios
dc.contributor.authorZegkos, Thomas
dc.contributor.authorKelpis, Timotheos
dc.contributor.authorPapamitsou, Theodora
dc.contributor.authorParcharidou, Despoina
dc.contributor.authorEfthimiadis, Georgios
dc.contributor.authorMeditskou, Soultana
dc.date.accessioned2023-01-31T11:55:16Z
dc.date.available2023-01-31T11:55:16Z
dc.date.issued2021
dc.description.abstractHypertrophic cardiomyopathy (HCM) is a diverse inherited disease affecting 1 in 500 individuals irrespective of gender and ethnicity. A fraction of HCM patients will eventually develop drug refractory dynamic obstruction of the left ventricular outflow tract. For such patients, septal myectomy is the procedure of choice to alleviate their symptoms and improve their quality of life. The current histopathological study, the first from the Greek region, aims to examine the hallmark histopathological characteristics of Hypertrophic Obstructive Cardiomyopathy in a population of patients undergoing septal myectomy at a single center over a ten year period. Medical records and histopathology specimens of thirty nine (n=39) patients were evaluated. The sample comprised 22 males (56.4%) and 17 females (43.6%). Mean patient age at myectomy was 53.9±16.7 years, ranging from 12 to 79 years. Maximal IVS thickness on echocardiography was available for 35 patients with a median value of 2.08cm. Peak resting LVOT Pressure Gradient was available for 33 patients with a mean value of 104.88±44.20 mmHg. Central tendency of each histopathological attribute expressed as the median value was: moderate for myocyte hypertrophy, mild for cytoplasmic vacuolization, moderate for subendocardial fibrosis, moderate for interstitial fibrosis, mild for replacement fibrosis, moderate for myofibrillar disarray and mild for capillary stenosis. Myocyte hypertrophy, present in all specimens, was positively correlated with maximal IVS thickness (tau-b=0.43, p=0.002). Replacement fibrosis was positively correlated with the grade of microvascular stenosis (tau-b=0.45, p=0.004). LVEF was negatively correlated with the grade of interstitial fibrosis (taub=−0.43, p=0.035) and with the extent of myocardial fiber disarray (tau-b=−0.42, p=0.034). Histopathological attributes were not correlated with patient gender or age thus proving that HCM has a histological phenotype unique to each patient, mainly depending on each specific sarcomeric mutationes
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dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 36, nº11 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-369
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128003
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypertrophic Cardiomyopathyes
dc.subjectMyectomyes
dc.subjectCardiac Pathologyes
dc.subjectCardiac Histologyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRoutine histopathology of septal myectomy for hypertrophic obstructive cardiomyopathy in a greek cohortes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº11 (2021)