Publication: Peptidergic innervation in the rat carotid body
after 2, 4, and 8 weeks of hypocapnic hypoxic exposure
Authors
Kusakabe, T. ; Hirakawa, H. ; Matsuda, H. ; Kawakami, T. ; Takenaka, T. ; Hayashida, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution and abundance of
neuropeptide-containing nerve fibers were examined in
the carotid bodies of rats exposed to hypocapnic hypoxia
(10% O2 in N2) for 2, 4, and 8 weeks. The carotid bodies
after 2, 4, and 8 weeks of hypoxic exposure were
enlarged by 1.2-1.5 times in the short axis, and 1.3-1.7
times in the long axis in comparison with the normoxic
control ones. The enlarged carotid bodies contained a
number of expanded blood vessels. Mean density per
unit area (104 µm2) of substance P (SP) and calcitonin
gene-related peptide (CGRP) immunoreactive fibers was
transiently high in the carotid bodies after 4 weeks of
hypoxic exposure, and decreased significantly to nearly
or under 50% after 8 weeks of hypoxic exposure.
Density of vasoactive intestinal polypeptide (VIP)
immunoreactive fibers increased significantly in all
periods of hypoxic exposure observed, and was
especially high in the carotid bodies after 4 weeks of
hypoxic exposure. Density of neuropeptide Y
immunoreactive fibers was unchanged in the carotid
bodies during hypoxic exposure. These characteristic
changes in the density of SP, CGRP, and VIP fibers in
the carotid bodies after 4 weeks of hypoxic exposure
suggest that the role of these neuropeptide-containing
fibers may be different in the carotid bodies after each of
three periods of hypoxic exposure, and that the
peptidergic innervation after 8 weeks of hypoxic
exposure may show an acclimatizing state.
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