Publication: High prevalence of human papillomavirus 16 in penile carcinoma
Authors
Pascual, A. ; Pariente, M. ; Godínez, J.M. ; Sánchez-Prieto, R. ; Atienzar, M. ; Segura, M. ; Poblet Martínez, Enrique
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
f Human Papillomavirus (HPV) in penile
carcinoma, we studied 49 patients with penile
carcinoma. Formalin-fixed, paraffin-embedded tissue
samples were collected from 64 samples of penile
carcinoma from the Hospital General Universitario
(Albacete, Spain). Cases were histologically classified
and the polymerase chain reaction (PCR) method was
used to detect the presence of HPV. Two sets of
consensus primers were used, the My09/My11, and the
GP5+/GP6+. All positive cases were sequenced in order
to establish the implicated genotype. Our results showed
that 38 of the 49 cases were positive for HPV (77,5%).
HPV16 appeared in 32 (84,2 %) of the 38 positive cases
and HPV18 in 4 (10,5%). Our data demonstrate that the
My09/My11 primers are more sensitive than
GP5+/GP6+ primers, although the combination of the
two sets of primers notably increased the total number of
HPV positive cases detected.
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