Publication: Epigenetic modulation of differentiation in CE44 teratocarcinoma
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Date
1999
Authors
Álvarez, A. ; Lacalle, J. ; Garcia-Sanz, M. ; Simón, J. ; Aréchaga, J. ; Hilario, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Teratocarcinoma is a mixed germ cell tumor
histologically composed of embryonal carcinoma cells
and embryonic and extraembryonic tissues. In the
present work we have used the CE44 teratocarcinoma,
which is a tumor cell line derived from the OTT6050
experimental tumor, to appreciate the influence
the microenvironment has on the modulation of
tumoral differentiation. For this, we have studied the
development of CE44 teratocarcinoma in primary
tumors (subcutaneous and intrasplenic) and in
experimental metastases (hepatic and pulmonary). CE44
teratocarcinoma shows variations in its capacity for
differentiation in so far as development is concerned
and, in hepatic metastases, we noticed a reparative
process of the intratumoral necrotic areas which in the
same cases were substituted by loose connective tissue.
Our results clearly suggest that the microenvironment
is decisive in the biological behaviour of
the teratocarcinoma cells and that epigenetic factors
influence the capacity for differentiation of the undifferentiated
tumoral cells.
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