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Intussusceptive angiogenesis facilitated by microthrombosis has an important example in angiolipoma. An ultrastructural and immunohistochemical study

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dc.contributor.authorDíaz Flores, Lucio
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorPino García, Maria
dc.contributor.authorGonzález Gómez, Miriam
dc.contributor.authorDíaz Flores Jr, Lucio
dc.contributor.authorCarrasco, Jose Luis
dc.contributor.authorÁlvarez Argüelles, Hugo
dc.contributor.authorMadrid Cuevas, Juan Francisco
dc.date.accessioned2023-03-08T15:56:16Z
dc.date.available2023-03-08T15:56:16Z
dc.date.issued2023
dc.description.abstractThe microvasculature of angiolipoma frequently presents thrombi. Our objectives are to assess whether intussusceptive angiogenesis (IA) participates in vasculature formation in non-infiltrating angiolipoma and, if so, to explore how thrombi are involved in the IA process. For this purpose, we studied angiolipoma specimens (n: 52), using immunohistochemistry, and confocal and electron microscopy. The results showed the presence of folds and pillars, hallmarks of IA, dividing the vessel lumen. Folds showed a cover formed by reoriented endothelial cells from the vessel wall, or from newly formed folds, and a core initially formed by thrombus fragments (clot components as transitional core), which was replaced by extracellular matrix and invaginating pericytes establishing numerous peg-andsocket junctions with endothelial cells (mature core). A condensed plasmatic electron-dense material surrounded and connected folds and pillars with each other and with the vascular wall, which suggests a clot role in fold/pillar arrangement. In conclusion, we contribute to IA participation in capillary network formation in angiolipoma and the immunohistochemical and ultrastructural events by which microthrombosis facilitates IA. Therefore, in addition to the histogenesis of angiolipoma, we provide an easily obtainable substrate for future studies on clot component action in IA, of clinical and therapeutic interestes
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.citationHistology and Histopathology Vol. 38, nº1 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-488
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129206
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAngiogenesises
dc.subjectIntussusceptive angiogenesises
dc.subjectAngiolipomaes
dc.subjectMicrocirculationes
dc.subjectThrombies
dc.subjectPericyteses
dc.subjectEndothelial cellses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleIntussusceptive angiogenesis facilitated by microthrombosis has an important example in angiolipoma. An ultrastructural and immunohistochemical studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication773c85c2-1260-4a4d-9543-f5a615648d71
relation.isAuthorOfPublication.latestForDiscovery773c85c2-1260-4a4d-9543-f5a615648d71
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Histology and histopathology Vol.38, nº1 (2023)