Publication: Hepatocyte apoptosis in hepatic iron overload diseases
Authors
Zhao, M. ; Laissue, J.A. ; Zimmermann, Astrid
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this retrospective study, we systematically
analyzed hepatocyte apoptosis in three situations of
hepatic iron overload (hereditary hemochromatosis;
hepatic iron overload of unknown reason; iron overload
due to hyperhemolysis or exogenous iron
administration). Apoptosis was assessed by use of DNA
nick end-labelling. The results suggest that hepatic iron
overload is associated with an increased apoptotic rate of
hepatocytes, and that iron-laden hepatocytes in
hemochromatosis behave, with respect to apoptosis,
differently from those in other states of iron overload.
The hepatocyte apoptotic rate tended to increase as a
function of the degree of iron storage. As in other
pathological liver changes studied so far, an elevated
apoptotic rate of hepatocytes predominated in the
pericentral parts of liver acini in hemochromatosis, but
not in the two other groups of hepatic iron overload.
Possible mechanisms for this difference are discussed,
particularly with respect to a participation of the Kupffer
cell system.
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