Publication: Ageing of the human entorhinal cortex
and subicular complex
Authors
Trillo, L. ; Gonzalo, L. M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Age-dependent changes in the entorhinal
cortex (EC) and subicular complex (SC) were studied
in 30 brains of patients who died between 14 and 86
years of age, without CNS impairment, as determined
by macro- and microscopic examination. The brains
were fixed in 10% formalin and embedded in paraffin.
Three series of corona1 EC and SC sections (7 pm)
were stained by Nissl, PAS or hematoxylin-eosin.
Using neuronal count and Kariometry, age-dependent
modifications were studied in layers 11, 111 and V of
the lateral area of the EC; in the pyramidal layer of
the subiculum (S), and in layer 11 of the presubiculum
(PS). Al1 EC layers studied presented a slight
(11-20%) although significant reduction up to 35
years, but from 35 to 75 years the decrease was not
significant. After 75 years the neuronal loss increased
slightly. The nuclear area decreased up to the age of
40-45 years, (10-18%) and augmented from this age up
to 75 years (10-14%). During the last period of life,
the nuclear area did not change. From 30-60 years,
pyramidal layer in the S showed a significant neuronal
loss (30%), thereafter, neuronal reduction was less. At
early years, the nuclear area decreased insignificantly
(15%), and from 35 years up to the most advanced age
studied, it increased significantly (13%).
In the PS, layer 11 manifested a cell loss throughout
the lifespan (32.9%) and the changes in the nuclear
area did not reach statistical significance due to the
dispersions of its values. These results lead to the
conclusion that the neuronal loss in EC is notably less
than in S and PS and, in general, than in other
centres. The sequence of neuronal loss is also different
in the EC and in the S. While in EC the maximal loss
occurs up to 35 years of age, in S the most pronounced
loss begins precisely after this age.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.