Assessment of MTNR1B type 2 diabetes genetic risk modification by shift work
and morningness-eveningness preference in the UK Biobank

Garaulet Aza, Marta

Publication:
Assessment of MTNR1B type 2 diabetes genetic risk modification by shift work and morningness-eveningness preference in the UK Biobank

dc.contributor.author	Garaulet Aza, Marta
dc.contributor.department	Fisiología
dc.date.accessioned	2021-02-11T12:46:18Z
dc.date.available	2021-02-11T12:46:18Z
dc.date.issued	2020
dc.description.abstract	Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes, however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N=189,488), we aimed to test the cross-sectional independent associations and joint interactions of these risk factors on odds of type 2 diabetes (n=5,042 cases) and HbA1c levels (n=175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk-allele associate with type 2 diabetes and HbA1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between selfreported morningness-eveningness preference and rs10830963 was seen on risk of type 2 diabetes, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when using accelerometer-derived sleep-midpoint as an objective measure of morningness-eveningness preference. Our findings suggest that the MTNR1B risk-allele carriers may not have greater vulnerability to shift work or morningness-eveningness preference.	es
dc.format	application/pdf	es
dc.format.extent	41	es
dc.identifier.uri	http://hdl.handle.net/10201/103057
dc.language	eng	es
dc.relation	Sociedad Española para el estudio de la Obesidad y el Ministerio de investigación, desarrollo e innovación, España es un país de cenadores tardíos ¿ un habito asociado a riesgo metabólico? (desde la observación, a través del mecanismo y hacia la intervención, SAF2017-84135-R	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 España	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/	*
dc.title	Assessment of MTNR1B type 2 diabetes genetic risk modification by shift work and morningness-eveningness preference in the UK Biobank	es
dc.title.alternative	MTNR1B type 2 diabetes genetic risk, shift work, and morningnesseveningness preference	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es